Viral encephalitis related to adalimumab in a 16-year-old Crohn's disease patient: case report and literature review - PubMed
3 hours ago
- #Viral Encephalitis
- #Crohn's Disease
- #Adalimumab
- A 16-year-old boy with Crohn's disease developed viral encephalitis after three months of adalimumab treatment.
- Symptoms included fever, dizziness, drowsiness, blurred vision, and optic disc edema; HHV-7 was identified in cerebrospinal fluid.
- Discontinuing adalimumab and administering acyclovir led to symptom resolution.
- Literature review found 11 adult Crohn's disease cases with neurological complications from adalimumab, including autoimmune encephalitis and Guillain-Barré syndrome.
- This is the first reported pediatric case of viral encephalitis linked to adalimumab, highlighting the need for vigilance in monitoring neurological symptoms.