IgE to cyclophilin Bet v 7 triggers mast cell activation and mediates cross-reactivity with Ara h 18 in children with seasonal allergic rhinitis - PubMed
3 days ago
- #Cyclophilins
- #MastCells
- #Allergy
- IgE to cyclophilin Bet v 7 triggers mast cell activation in children with seasonal allergic rhinitis.
- Bet v 7 shows cross-reactivity with Ara h 18, indicating shared IgE-binding properties.
- Functional assays demonstrate Bet v 7 activates mast cells in a dose-dependent manner.
- Bet v 7 remains active after mild heat treatment and saliva digestion.
- Strong correlation found between IgE levels to Bet v 7 and Ara h 18 (r = 0.996, p < 0.0001).
- Findings suggest cyclophilins should be considered in molecular diagnostic panels for SAR.