Mfsd2a is important for maintaining epidermal homeostasis - PubMed
2 days ago
- #lysophosphatidylcholine transport
- #keratinocyte differentiation
- #epidermal homeostasis
- Mfsd2a is crucial for maintaining epidermal homeostasis by transporting lysophosphatidylcholine (LPC).
- Epidermal-specific deficiency of Mfsd2a in mice leads to dermatitis and defective desquamation.
- Mfsd2a deficiency alters the phospholipidome, reducing linoleic acid in phosphatidylcholine and triglycerides.
- LPC-oleate and LPC-linoleate promote keratinocyte differentiation in an Mfsd2a-dependent manner.
- Mfsd2a mediates uptake of plasma-derived LPC, essential for keratinocyte phosphatidylcholine pools and differentiation.