The role of KPNA3 in multiple myeloma: implications for targeting nuclear import - PubMed
7 hours ago
- #Nuclear Import
- #KPNA3
- #Multiple Myeloma
- KPNA3 is highly expressed in multiple myeloma (MM) and inversely correlates with patient prognosis.
- Knockdown of KPNA3 inhibits MM cell proliferation, promotes apoptosis, and increases drug sensitivity.
- KPNA3 knockdown affects ALDH2 transcription and hedgehog pathway activity.
- Ivermectin (IVM) binds to KPNA3, reducing its protein levels and promoting MM cell apoptosis.
- IVM and selinexor show synergistic anti-MM effects in vitro and in vivo.
- Targeting nuclear import via KPNA3 is a promising therapeutic strategy for MM.