CASPR2 Autoimmune Antibodies Induce Neuronal Hyperactivity in Human Brain Organoids - PubMed
3 hours ago
- #hyperexcitability
- #neurodevelopment
- #autoantibodies
- Gestational transfer of brain-reactive antibodies is a risk factor for neurodevelopmental disorders.
- CASPR2 is a target for pathogenic maternal autoantibodies that may interfere with fetal neurodevelopment.
- Human neural organoids exposed to anti-CASPR2 antibodies showed increased spontaneous synaptic activity.
- CASPR2 antibody exposure enhanced maximal frequency of action potential firing and spontaneous network activity.
- The findings suggest neuronal hyperexcitability, a phenotype seen in neurodevelopmental disorder models.
- CASPR2 may regulate voltage-gated potassium channels, with autoantibodies driving hyperexcitability.