A prospective external validation of the GRade, Age, Nodes and Tumor (GRANT) score in the ECOG-ACRIN EA8143 PROSPER trial - PubMed
5 days ago
- #prognostic model
- #renal cell carcinoma
- #GRANT score
- The GRANT score, integrating age, tumor size, grade, and nodal status, was validated in the ECOG-ACRIN EA8143 PROSPER trial.
- Patients were classified into favorable (0-1 risk factors) and unfavorable (2-4 risk factors) groups based on the GRANT score.
- Favorable group showed significantly longer median RFS (61.1 vs 36.9 months) and OS (median not reached) compared to the unfavorable group.
- The c-index was 0.63 for RFS and 0.66 for OS, indicating moderate discrimination.
- Better prognostic performance was observed in non-clear cell RCC for both RFS (HR: 0.13; c-index: 0.74) and OS (HR: 0.14; c-index: 0.74).
- The study supports the use of the GRANT score in clinical practice for risk stratification in surgically treated RCC patients.