Optineurin enhances the chemoresistance by activating mitophagy in acute myeloid leukemia with NPM1 mutation - PubMed
a day ago
- #acute myeloid leukemia
- #chemoresistance
- #mitophagy
- Optineurin (OPTN) enhances chemoresistance in NPM1-mutated AML by activating mitophagy.
- Hyperactivated mitophagy is a metabolic vulnerability in NPM1-mutated AML, driven by OPTN upregulation.
- OPTN-mediated mitophagy maintains mitochondrial homeostasis, promoting leukemia cell proliferation and drug resistance.
- Inhibition of OPTN suppresses mitophagy, disrupts mitochondrial homeostasis, and sensitizes cells to cytarabine (Ara-C).
- Targeting OPTN-mediated mitophagy is a promising strategy to overcome chemoresistance in NPM1-mutated AML.