HDAC1 modulates sepsis-induced immunosuppression by driving the exhaustion of CD8+ T cells - PubMed
4 hours ago
- #immunosuppression
- #sepsis
- #HDAC1
- Sepsis-induced immunosuppression is a critical factor in high mortality rates in intensive care units.
- HDAC1 plays a key role in driving CD8+ T cell exhaustion, contributing to immunosuppression in sepsis.
- Clinical data shows reduced CD8+ T cell levels in sepsis patients correlate with worse outcomes.
- In a mouse sepsis model, CD8+ T cell exhaustion was observed, and adoptive transfer of these cells reduced mortality.
- HDAC1 expression is upregulated in CD8+ T cells from sepsis patients.
- Inhibition of HDAC1 preserves CD8+ T cell function by reducing inhibitory molecules like PD-1.
- HDAC1 interacts with NFAT1, promoting its nuclear translocation and enhancing inhibitory molecule expression.
- Targeting HDAC1 could be a therapeutic strategy to reverse immunosuppression in sepsis.