Non-gonadal PIWIL1/Aubergine drives regenerative and tumorigenic stem cell proliferation and tumorigenesis in the intestine - PubMed
7 hours ago
- #intestinal regeneration
- #tumorigenesis
- #PIWIL1/Aubergine
- PIWI pathway's role in intestine extends beyond germline transposon suppression.
- Aubergine (Aub), a PIWI protein, is upregulated by reactive oxygen species after damage.
- Aub drives regenerative intestinal stem cell proliferation via enhanced protein synthesis, including Myc and Sox21a translation.
- Aub's function in stem cells is uncoupled from its piRNA regulatory role.
- Aub and mammalian PIWIL1 promote tumorigenic growth in Drosophila and human organoids, linking to colorectal cancer.