Sphingosine 1-Phosphate Receptor 1 and 5 Reciprocally Regulate IL-13 and IL-9 Production in Atopic Dermatitis - PubMed
3 hours ago
- #S1P Signaling
- #Atopic Dermatitis
- #Cytokine Regulation
- Atopic dermatitis (AD) is linked to Th2, Th9, and Th22 immune responses.
- Sphingosine 1-phosphate (S1P) signaling influences IL-13 and IL-9 production in AD.
- S1PR5 suppresses IL-13 and IL-9, while S1PR1 enhances their production.
- AD patients have higher serum S1P levels compared to healthy controls.
- The study highlights the role of lipid mediators in Th2/Th9-driven inflammation in AD.