Plasma proteomic trajectories before the onset of neurodegenerative diseases - PubMed
4 hours ago
- #biomarkers
- #neurodegenerative diseases
- #proteomics
- Study aimed to identify proteins linked to neurodegenerative diseases (NDDs) and track changes before onset.
- Analyzed plasma proteomic data from UK Biobank using Cox regression and Lasso regression models.
- Identified 14 proteins for Alzheimer's disease (AD), 35 for Parkinson's disease (PD), and one for ALS.
- Neuroinflammation and extracellular matrix remodeling may be common pathways in NDDs.
- Highlighted the landscape of plasma protein changes prior to NDD onset.