PSMA4 as a Druggable Target in Hidradenitis Suppurativa: Evidence From Mendelian Randomization and Single-Cell Transcriptomics - PubMed
8 days ago
- #Hidradenitis Suppurativa
- #Therapeutic Targets
- #Mendelian Randomization
- PSMA4 and MAST3 identified as potential therapeutic targets for Hidradenitis Suppurativa (HS) through Mendelian randomization and transcriptomic analysis.
- PSMA4 is upregulated in HS lesions and predominantly enriched in CD4+ T cells, promoting inflammation via the TNF pathway.
- MAST3 is downregulated in HS lesions, suggesting its role may be protective or anti-inflammatory.
- The study integrates colocalization, single-cell RNA sequencing, and cell-cell communication analyses to validate targets.
- Findings offer novel avenues for treatment development in HS, a condition with limited therapeutic options.