Childhood Obesity and Cardiac Risk in Youth: Emerging Challenges Toward 2050 - PubMed
4 hours ago
- #pediatric obesity
- #public health
- #cardiovascular risk
- Childhood obesity is rising globally, affecting over 381 million children and posing a major public health challenge.
- It increases risks of adult obesity and cardiovascular diseases like atherosclerosis, coronary artery disease, hypertension, dysglycemia, and dyslipidemia.
- Risk factors include genetic predispositions (via GWAS studies), reduced physical activity, prolonged screen time, and poor diet.
- Management strategies include lifestyle modifications, pharmacotherapy (e.g., GLP-1 agonists like semaglutide and liraglutide), and bariatric surgery.
- Emerging therapies include tirzepatide, cagrilintide plus semaglutide, oral agents (orforglipron, danuglipron), and retatrutide, but are still investigational.
- Public health initiatives like WHO's GAPPA emphasize prevention, but gene therapy remains experimental.
- Multifaceted interventions combining public health efforts, behavioral changes, and novel therapies are needed to reduce cardiovascular risks and improve long-term health.