Association of serum uric acid to high density lipoprotein cholesterol ratio with stroke - PubMed
4 hours ago
- #uric acid
- #stroke
- #HDL-C
- Study explores the association between the uric acid to HDL-C ratio (UHR) and stroke risk using data from the China Health and Retirement Longitudinal Study (CHARLS) cohort.
- UHR was significantly associated with increased stroke risk, with the highest UHR group having 1.61 times the risk of the lowest group.
- The association between UHR and stroke risk was significant in non-diabetic populations but not in diabetic populations.
- UHR mediated 18% of the association between BMI and stroke risk.
- No significant multiplicative or additive interactions were found between BMI and UHR on incident stroke.
- Restricted cubic spline analysis showed a linear dose-response relationship between UHR and stroke risk.
- The study suggests UHR, especially when combined with BMI, could be valuable for stroke risk stratification.