Fibroblast growth factor 21 with molybdenum nanodots in a self-contracting thermosensitive hydrogel promotes diabetic wound repair by reprogramming lipid metabolism - PubMed
7 hours ago
- #Diabetic wound
- #FGF21
- #Hydrogel
- Fibroblast growth factor 21 (FGF21) combined with molybdenum nanodots (MNDs) in a self-contracting thermosensitive hydrogel promotes diabetic wound repair.
- The hydrogel addresses impaired re-epithelialization and microvascular dysfunction in diabetic wounds by correcting lipid metabolism and reducing oxidative stress.
- FGF21 corrects lipid metabolism abnormalities and restores energy metabolism homeostasis.
- MNDs act as efficient ROS scavengers, alleviating oxidative stress and blocking the 'ROS-inflammation' feedback loop.
- The self-contracting PNI hydrogel provides mechanical traction to enhance keratinocyte migration and epithelial layer reconstruction.
- The composite hydrogel significantly accelerates wound closure in diabetic mouse models through a triple synergistic mechanism.
- The study demonstrates the potential of multi-target synergistic intervention for chronic wound healing.