Tetrahedral framework nucleic acid delivery of emodin enables precision antibacterial and anti-inflammatory therapy for drug-resistant Staphylococcus aureus - PubMed
4 hours ago
- #Nanoplatform
- #Staphylococcus aureus
- #Emodin
- Tetrahedral framework nucleic acids (tFNAs) were used to deliver emodin for targeted antibacterial and anti-inflammatory therapy against drug-resistant Staphylococcus aureus.
- Emodin, a natural anthraquinone, has dual antibacterial and anti-inflammatory properties but suffers from poor solubility and rapid clearance.
- The designed nanoplatform includes a Staphylococcus aureus-specific aptamer for targeted bacterial recognition and sustained release of emodin.
- The system enhanced emodin's efficacy against methicillin-resistant S. aureus (MRSA), inhibited biofilm formation, and disrupted mature biofilms.
- In murine models, the Apt-tFNAs-Emo reduced bacterial burden, alleviated oxidative stress, suppressed proinflammatory cytokines, and accelerated wound healing.
- The study presents a promising therapeutic strategy for multidrug-resistant S. aureus skin infections by combining antimicrobial delivery, biofilm disruption, and immunomodulation.