Synergistic Antitumor Efficacy of Radiofrequency Ablation Combined With TROP2-CAR-T Cells in a Xenograft Mouse Model of Lung Adenocarcinoma - PubMed
7 hours ago
- #Immunotherapy
- #Lung Cancer
- #Combination Therapy
- TROP2-CAR-T cells demonstrated potent antigen-specific cytotoxicity against lung adenocarcinoma (LUAD) cells in vitro.
- In a xenograft mouse model, both radiofrequency ablation (RFA) and TROP2-CAR-T monotherapy suppressed tumor growth, with their combination showing a synergistic antitumor effect.
- The combination therapy of RFA and TROP2-CAR-T cells improved antitumor efficacy and safety profile without observed hepatic or renal toxicity in vivo.