RASA2 deletion rescues immune synapse dysfunction, enhancing CAR T cell efficacy against DMGs - PubMed
7 hours ago
- #CAR T-cell therapy
- #RASA2 deletion
- #immune synapse
- Limited efficacy of B7-H3 CAR T-cells against DMGs is due to impaired immune synapse formation.
- RASA2 deletion improves immune synapse quality, enhancing CAR T-cell activation, cytokine secretion, and anti-tumor response.
- RASA2-deleted CAR T-cells show enhanced calcium flux, signaling molecule accumulation, and actin dynamics, leading to better in vitro and in vivo functionality.