Gut Microbiota Regulates Brain-Bone Axis to Influence Osteoporosis Pathogenesis and Treatment - PubMed
4 hours ago
- #osteoporosis
- #gut-microbiota
- #bone-metabolism
- Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and increased fracture risk.
- Gut microbiota plays a crucial role in bone metabolism through microbial metabolites, immune regulation, and neuroendocrine signaling.
- Short-chain fatty acids from gut microbiota suppress osteoclast differentiation and enhance calcium absorption.
- Gut dysbiosis can lead to bone loss by impairing intestinal barrier integrity and increasing proinflammatory cytokines.
- The gut-brain-bone axis links the central nervous system, gut-derived signals, and skeletal remodeling.
- Chronic stress and neurodegenerative conditions activate pathways that favor bone resorption.
- Estrogen deficiency disrupts bone homeostasis and alters gut microbial composition, contributing to postmenopausal bone loss.
- Therapeutic strategies like probiotics, prebiotics, and fecal microbiota transplantation show potential in improving bone metabolism.
- Future research should focus on multiomics approaches and clinical trials to clarify microbiome-bone interactions.