Diabetes-related foot disease and sarcopenia-related traits: evidence from US and Chinese cohorts and mendelian randomization - PubMed
3 days ago
- #Diabetes-related foot disease
- #Sarcopenia
- #Mendelian randomization
- Diabetes-related foot disease (DFD) is associated with an increased risk of sarcopenia-related traits (SRTs).
- Cross-sectional analysis from NHANES and CHARLS showed significant associations between DFD and sarcopenia indicators.
- Longitudinal analysis in CHARLS confirmed DFD's association with lower physical performance and grip strength over time.
- Mendelian randomization suggests a causal link between diabetic complications and reduced muscle strength and gait speed.
- DFD is identified as an independent risk factor for accelerating sarcopenia onset in diabetes patients.