Efficacy and safety of sacubitril/valsartan in patients on peritoneal dialysis: a systematic review and meta-analysis - PubMed
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- Sacubitril/valsartan improved left ventricular ejection fraction (LVEF) in peritoneal dialysis patients.
- The treatment significantly reduced NT-proBNP levels and systolic blood pressure (SBP).
- No significant changes were observed in left atrial diameter (LAD) or left ventricular end-diastolic dimension (LVDd).
- Hyperkalemia incidence was modest at 11.94%, while hypotension and angioedema were rare.
- The safety profile was acceptable, supporting potential benefits, though further RCTs are needed.