SPAG5 promotes ferroptosis and enhances chemotherapy efficacy in locally advanced colorectal cancer via upregulating intracellular ROS levels - PubMed
8 hours ago
- #Chemotherapy
- #Colorectal Cancer
- #Ferroptosis
- SPAG5 promotes ferroptosis and enhances chemotherapy efficacy in locally advanced colorectal cancer (LACRC).
- High SPAG5 expression correlates with improved progression-free survival (PFS) and overall survival (OS) in CRC patients undergoing chemotherapy.
- SPAG5 overexpression increases reactive oxygen species (ROS), promoting ferroptosis and chemotherapy sensitivity.
- SPAG5 depletion reduces ROS levels, attenuates ferroptosis, and decreases chemotherapy efficacy.
- Inhibition of ROS reverses the chemotherapy-sensitizing effect of SPAG5.
- SPAG5 may serve as a biomarker and therapeutic target to enhance chemotherapy response in LACRC.