The Roles of A Proliferation-Inducing Ligand (APRIL) and B-Cell Activating Factor (BAFF) in IgA Nephropathy - PubMed
4 days ago
- #IgA nephropathy
- #B-cell activation
- #Autoimmune disease
- Elevated levels of galactose-deficient IgA1 are critical in IgA nephropathy (IgAN) pathogenesis.
- Abnormal B-cell glycosylation pathways produce autoantigens that form immune complexes when recognized by autoantibodies.
- APRIL and BAFF are key cytokines controlling B-cell development and antibody-secreting cell differentiation.
- Targeting APRIL with or without BAFF is a promising treatment strategy for IgAN.
- Early clinical trial data show promising results for APRIL/BAFF-targeted therapies in IgAN.