[Adverse reaction surveillance analysis of domestic human papillomavirus vaccines with different production processes] - PubMed
4 hours ago
- #adverse reactions
- #HPV vaccines
- #vaccination schedule
- A study compared two domestic HPV vaccines (Walrinvax and Cecolin) in individuals aged 9-30, focusing on vaccination rates and adverse reactions.
- The two-dose regimen (ages 9-14) showed higher full and timely vaccination rates than the three-dose regimen (ages 15-30).
- Overall adverse reaction rate was 18.78%, with local reactions at 8.02% and systemic reactions at 10.76%.
- Most common adverse reactions were injection site pain (4.97%) and fever (4.47%). No severe (grade 4) or special-interest events occurred.
- No significant difference in adverse reaction rates between the two domestic HPV vaccines (13.96% vs 17.46%).
- The 9-14 age group had a significantly lower adverse reaction rate (9.77%) compared to the 15-30 age group (24.91%).
- Both vaccines demonstrated favorable safety with mostly mild reactions, and the two-dose schedule reduced adverse reactions and improved compliance.