Bioengineered ROS-tolerant probiotic reshapes gut microbiota-host axis to ameliorate type 2 diabetes in male mice - PubMed
4 hours ago
- #probiotics
- #type 2 diabetes
- #gut microbiota
- Bioengineered ROS-tolerant probiotic (REcN-F/Ca) developed to target type 2 diabetes (T2DM).
- Probiotic consortium derived from Escherichia coli Nissle 1917 (EcN) with enhanced oxidative stress tolerance.
- REcN-F/Ca improves gut microbiota diversity and enriches butyrogenic taxa (Lachnospiraceae and Blautia).
- Restores short-chain fatty acids (SCFAs) and activates PPAR signaling for lipid metabolism regulation.
- In obese male mice, REcN-F/Ca reduces weight gain (-25.4%) and insulin resistance (HOMA-IR: -73.2%).
- Demonstrates systemic metabolic improvements, including glucose homeostasis restoration.
- Potential paradigm for managing metabolic syndrome via gut microbiota-host axis modulation.