A longitudinal study of children identifies antibody Fc-mediated functions and antigen targets of immunity to Plasmodium vivax malaria - PubMed
3 hours ago
- #malaria vaccines
- #antibody functions
- #Plasmodium vivax malaria
- A longitudinal study focused on children in Papua New Guinea to understand immunity to Plasmodium vivax malaria.
- Identified antibody functions and antigen targets, including Fcγ receptor interactions and complement fixation.
- Discovered specific antigens targeted by protective antibodies, offering insights for vaccine development.
- Evaluated thousands of antigen combinations to find the most protective subsets for multi-antigen vaccines.
- The study provides leads for developing vaccines that elicit multi-functional antibody responses to combat P. vivax malaria.