Human umbilical cord mesenchymal stem cells therapy for Alzheimer's disease: a systematic review and meta-analysis of mouse models - PubMed
3 hours ago
- #Alzheimer's disease
- #stem cell therapy
- #meta-analysis
- Human umbilical cord mesenchymal stem cells (hUCMSCs) therapy shows promise for Alzheimer's disease (AD) in mouse models.
- hUCMSCs significantly improved spatial learning and memory, reduced β-amyloid levels, increased brain-derived neurotrophic factor, and decreased neuronal apoptosis in AD mice.
- The efficacy of hUCMSCs therapy is dose- and route-dependent, with intravenous injection of medium to high doses (≥1 × 10^6 cells) being most effective for cognitive improvement.
- Low-dose administration via intravenous, lateral ventricle, and cortical routes was effective for amyloid-β clearance, but bilateral hippocampal injection showed no significant benefits.
- The study provides evidence supporting the potential clinical application of hUCMSCs for AD, highlighting the importance of transplantation route and dose.