ILA-producing bifidobacterium bifidum ameliorates chronic kidney disease via AHR signaling by modulating the gut-kidney axis - PubMed
3 days ago
- #probiotics
- #chronic kidney disease
- #gut-kidney axis
- ILA-producing Bifidobacterium bifidum strains FL228.1 and ZL.1 were isolated for their potential to ameliorate chronic kidney disease (CKD).
- Strain ZL.1 showed significant efficacy in improving renal injury, restoring gut barrier function, and correcting gut microbiota dysbiosis in a CKD mouse model.
- The beneficial effects are mediated through the activation of the aryl hydrocarbon receptor (AHR) signaling pathway by indole-3-lactic acid (ILA), inhibiting NLRP3 inflammasome activation.
- This study highlights the potential of targeting tryptophan metabolism with probiotics as a therapeutic strategy for CKD via the gut-kidney axis.