Advances in Microenvironment-Responsive Biomaterials for Spinal Cord Injury Repair - PubMed
4 hours ago
- #drug delivery
- #biomaterials
- #spinal cord injury
- Spinal cord injury (SCI) leads to permanent motor and sensory loss due to a dysfunctional pathological microenvironment.
- Secondary injuries trigger signals like dysregulated pH, elevated ROS, increased enzyme activity, excessive inflammation, and altered biophysical cues.
- Microenvironment-responsive biomaterials can recognize and neutralize these signals, improving treatment accuracy and effectiveness.
- These biomaterials exploit disease-specific signals for controlled drug release.
- The review covers design principles, response mechanisms, characteristics, and types of SCI microenvironment-responsive biomaterials.
- Recent advances, regeneration mechanisms, preclinical applications, and clinical translation prospects are summarized.
- Challenges and future developments in biomaterial-based therapeutic strategies are discussed.