Exosomes in diabetic kidney disease: pathogenesis, biomarker discovery, and emerging therapeutics-a comprehensive systematic review - PubMed
3 hours ago
- #Biomarkers
- #Exosomes
- #Diabetic kidney disease
- Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a leading cause of end-stage renal disease.
- Exosomes, a type of extracellular vesicle, play a key role in intercellular communication and are involved in DKD pathogenesis.
- Urinary exosomes show dynamic changes in diabetes, making them potential biomarkers for DKD.
- Exosomes carry proteins, lipids, and nucleic acids, influencing cellular homeostasis and disease processes.
- The review explores exosome roles in DKD pathology, diagnostic biomarkers, and therapeutic applications.
- Future research directions include AI-integrated multi-omics, large-scale clinical trials, and personalized medicine approaches.