Stabilin-1+ lipid-associated macrophages promote lung adenocarcinoma liver metastasis and osimertinib resistance through impairing macrophage phagocytosis via SIRPα-CD47 axis - PubMed
a day ago
- #osimertinib resistance
- #macrophages
- #lung adenocarcinoma
- Stabilin-1+ (STAB1+) lipid-associated macrophages promote lung adenocarcinoma (LUAD) liver metastasis and osimertinib resistance.
- STAB1+ lipid-associated macrophages impair macrophage phagocytosis via the SIRPα-CD47 'don't eat me' signaling axis.
- CXCL12 chemokine from liver metastatic LUAD cells recruits monocytes, differentiating them into STAB1+ lipid-associated macrophages.
- STAB1 overexpression upregulates SIRPα-CD47, reducing phagocytic ability of macrophages towards tumor cells.
- Inhibition of STAB1+ lipid-associated macrophages suppresses osimertinib resistance and liver metastasis in LUAD models.