Glioma-induced DNMT3A reduction in microglia promotes an anti-tumoral phenotype - PubMed
4 hours ago
- #DNMT3A
- #glioblastoma
- #microglia
- Glioblastoma promotes recruitment and activation of microglia into a tumor-supportive phenotype.
- Glioma stimulation reduces DNMT3A in microglia, leading to DNA demethylation and anti-tumoral gene expression.
- Repression of Dnmt3a in microglia maintains anti-tumoral effects in vitro and in vivo.
- Targeting Dnmt3a with antisense oligonucleotides reduces tumor growth in a glioblastoma mouse model.
- Microglial DNMT3A is a potential therapeutic target for brain tumors involving microglia.