RNA-Binding Proteins TDP-43 and FUS Promote R-Loop Resolution and Regulate Transcription Termination - PubMed
4 days ago
- #Transcription termination
- #Neurodegenerative diseases
- #RNA-binding proteins
- TDP-43 and FUS are RNA-binding proteins linked to neurodegenerative diseases like ALS and FTD.
- These proteins aid in transcription termination via the R1810me2s-SMN pathway, resolving R-loops.
- Disruption of TDP-43 and FUS recruitment leads to defective RNAPII termination, R-loop accumulation, and DNA damage.
- TDP-43's RNA-binding activity is crucial for R-loop resolution and efficient transcription termination.
- The study connects TDP-43/FUS dysfunction with genome instability and ALS/FTD pathogenesis.