Iron overloaded M0 macrophages regulate hematopoietic stem cell proliferation and senescence via the Nrf2/Keap1/HO-1 pathway - PubMed
4 hours ago
- #Iron Overload
- #Nrf2 Pathway
- #Hematopoietic Stem Cells
- Iron overload in M0 macrophages impairs phagocytic activity and increases ROS and iNOS expression.
- Co-culture with iron-overloaded macrophages inhibits HSCs proliferation, causes cell cycle arrest, and accelerates senescence, indicated by increased P16 and SA-β-gal and decreased HOXB4 and RUNX1.
- Activation of the Nrf2/Keap1/HO-1 pathway using TMC reverses the negative effects on HSCs, restoring proliferation and reducing oxidative damage.