Curcuma longa-derived extracellular vesicle-like particles ameliorate retinal neovascularization through HIF-1α and NRF2 signaling - PubMed
3 hours ago
- #HIF-1α/NRF2 signaling
- #retinal neovascularization
- #Curcuma longa
- Curcuma longa-derived extracellular vesicle-like particles (CL-EVLPs) show potential in treating retinal neovascularization.
- CL-EVLPs were extracted and characterized, showing typical EV-like characteristics with a mean diameter of 140.7 nm.
- In a mouse model of oxygen-induced retinopathy (OIR), CL-EVLPs reduced pathological neovascular tufts and avascular zones.
- CL-EVLPs decreased reactive oxygen species (ROS) production in retinas and inhibited HIF-1α/VEGF/ERK signaling.
- The particles activated the NRF2/HO-1 antioxidant pathway, showing regulatory antioxidant and anti-inflammatory effects.
- In vitro experiments confirmed CL-EVLPs inhibit endothelial cell viability and alleviate oxidative stress in microglia.
- Network pharmacology and metabolomics identified cargo molecules like curcumin derivatives contributing to therapeutic effects.
- CL-EVLPs present a multitarget therapeutic strategy with clinical potential for retinal neovascular diseases.