SIRT3 alleviates periodontitis inflammation by inhibiting macrophage M1 polarization regulation via FOXO3/NRF2 - PubMed
a day ago
- #Periodontitis
- #SIRT3
- #Macrophage polarization
- SIRT3 expression is significantly downregulated in periodontitis tissues.
- Activation of SIRT3 by honokiol suppresses LPS-induced M1 macrophage polarization and reduces TNF-α and IL-6 secretion.
- FOXO3 is identified as a direct binding partner of SIRT3 through bioinformatic analysis and co-IP.
- SIRT3 overexpression activates the FOXO3/NRF2 pathway, which is reversed by FOXO3 inhibition.
- In vivo, SIRT3 overexpression in mice reduces inflammatory cell infiltration, shifts macrophage phenotype from M1 to M2, and decreases TNF-α and IL-6 levels.
- SIRT3 ameliorates alveolar bone injury by suppressing M1 macrophage polarization via the FOXO3/NRF2 axis.