Diffuse Pleural Mesothelioma in Young (Age ≤50 Years) and Very Young (Age ≤35 Years) Patients: Clinical Characteristics, Genomics, and Survival - PubMed
5 hours ago
- #young patients
- #genomics
- #mesothelioma
- Study focuses on diffuse pleural mesothelioma (DPM) in young (≤50 years) and very young (≤35 years) patients.
- 39% of the 273 identified patients were female, with 40% reporting occupational asbestos exposure (16% in very young vs. 45% in young).
- 16% had a personal history of cancer, and 70% had a family history of cancer (commonly breast, lung, and colon).
- Frequent somatic gene alterations included BAP1 (47%), NF2 (38%), CDKN2A/B (25%), and TP53 (21%).
- Very young patients showed fewer BAP1 alterations (13% vs. 63%) and lower tumor mutational burden (0.9 vs. 1.8 mut/mB).
- Somatic alterations in CDKN2B were more frequent in females (42% vs. 12% in males).
- Findings suggest divergent underlying biology in young DPM patients, with implications for diagnosis even without asbestos exposure.