Renin-angiotensin system blockade attenuates brain mitochondrial dysfunction, oxidative stress, and neuroinflammation associated with hypertension, metabolic disorders, and aging - PubMed
4 hours ago
- #Renin-angiotensin system
- #Oxidative stress
- #Neurodegeneration
- Renin-angiotensin system blockade attenuates brain mitochondrial dysfunction, oxidative stress, and neuroinflammation linked to hypertension, metabolic disorders, and aging.
- The central nervous system has two RAS branches: ACE/Ang II/AT1 axis and ACE2/Ang-(1-7)/Mas axis.
- Neuroinflammation is driven by oxidative stress from reactive oxygen and nitrogen species, primarily in mitochondria.
- Conditions like obesity, hypertension, metabolic disorders, and aging accelerate these processes, leading to cognitive decline and neurodegenerative diseases.
- Therapeutic interventions targeting RAS, such as angiotensin receptor blockers and ACE2 activators, may prevent and treat vascular dementia and neurodegenerative diseases.