Wogonin ameliorates osteoarthritis by targeting the STAT3/PIM1 axis to attenuate chondrocyte senescence - PubMed
9 hours ago
- #Osteoarthritis
- #STAT3/PIM1 axis
- #Wogonin
- Wogonin, derived from Scutellaria baicalensis Georgi roots, shows therapeutic efficacy against osteoarthritis (OA).
- The study investigates Wogonin's mechanism by targeting the STAT3/PIM1 axis to attenuate chondrocyte senescence.
- Experiments included IL-1β-induced C28/I2 cells and DMM mice to simulate OA, evaluating Wogonin's effects through various assays.
- Wogonin was found to ameliorate cartilage injury, inhibit synovitis, and reduce osteophyte formation in DMM mice.
- It promotes proliferation, hinders apoptosis, suppresses matrix degradation, and stimulates matrix synthesis in chondrocytes.
- Wogonin directly binds to STAT3, inhibiting its activation and reversing pathological changes associated with OA.
- The findings suggest Wogonin's potential as a therapeutic agent for OA by targeting chondrocyte senescence.