Injectable Metal-Free Carbon Dot-Integrated Hydrogel for Regulating Inflammation via Macrophage Metabolic Reprograming in Spinal Cord Injury Therapy - PubMed
3 hours ago
- #carbon dots
- #spinal cord injury
- #hydrogel
- Excessive oxidative stress after spinal cord injury (SCI) leads to pro-inflammatory reactions, hindering nerve regeneration.
- Metal-free carbon dots (D-CDs) eliminate ROS and reprogram macrophage metabolism via the P53 signaling pathway.
- An injectable chitosan-based hydrogel (QP hydrogel) enables sustained local delivery of D-CDs at the injury site.
- D-CDs@QP hydrogel promotes macrophage M2-polarization, enhances neurogenesis, and suppresses astrocytic differentiation.
- In a mouse SCI model, D-CDs@QP improved motor and bladder function recovery.
- The study presents a metal-free carbon nanozyme-hydrogel system to combat neuroinflammation and promote neuroregeneration.