Routine inflammatory indices modify clonal hematopoiesis-related prognostic risk in patients undergoing percutaneous coronary intervention: a real-world cohort study - PubMed
3 hours ago
- #Clonal hematopoiesis
- #Inflammatory indices
- #PCI prognosis
- CHIP mutations were found in 21.95% of PCI patients and were independently associated with increased risks of all-cause and cardiac mortality.
- Systemic inflammatory burden significantly modified the association between CHIP and mortality risk, with elevated inflammation amplifying CHIP-related mortality risk.
- No overall association was observed between CHIP and 5-year MACCE, but significant associations emerged under elevated levels of certain inflammatory indices.
- Incorporating CHIP into the GRACE score improved long-term mortality prediction after PCI.
- The study highlights the potential benefit of managing inflammatory burden in PCI patients with CHIP.