ML364 ameliorates NLRP3-induced inflammatory response - PubMed
3 hours ago
- #NLRP3 inflammasome
- #USP2
- #ML364
- ML364 inhibits NLRP3-induced inflammatory response by targeting the deubiquitinase USP2.
- USP2 promotes NLRP3 inflammasome activation by stabilizing NLRP3 through deubiquitination of its NACHT domain.
- Pharmacological inhibition of USP2 with ML364 reduces inflammatory responses in models of peritonitis and colitis.
- The study highlights ML364 as a potential therapeutic for NLRP3 inflammasome-associated diseases.