Neutrophil transcriptomics in SLE reveals intrinsic disease signatures, shared ex vivo adaptation, and transcriptional reset after CAR T-cell therapy - PubMed
3 hours ago
- #Neutrophil transcriptomics
- #SLE
- #CAR T-cell therapy
- Neutrophil transcriptomics in SLE reveals intrinsic disease signatures and shared ex vivo adaptation.
- Transcriptional reset observed after CAR T-cell therapy in SLE patients.
- 258 differentially expressed genes identified between SLE and healthy neutrophils.
- Genes enriched in interferon-related and DNA damage repair pathways (upregulated) and ribosomal protein genes (downregulated).
- Ex vivo adaptation showed shared activation pathways like NF-κB and apoptosis in both SLE and healthy neutrophils.
- LPS stimulation demonstrated retained inflammatory response in SLE neutrophils.
- CAR T-cell therapy realigned neutrophil transcriptomic profiles with healthy controls by 3 months posttreatment.
- Findings suggest potential therapeutic strategies targeting both adaptive and innate immunity in SLE.