Synergistic delivery of ginseng exosomes and biomimetic melanosomes via temporally controlled hydrogel microneedles restrain the pathologic triad of vitiligo - PubMed
4 hours ago
- #hydrogel-microneedles
- #repigmentation
- #vitiligo
- Engineered hydrogel microneedles deliver ginseng exosomes (G-Exos) and biomimetic polydopamine nanoparticles (PDA@PEGs) to target vitiligo's pathogenic triad: oxidative stress, inflammation, and melanocyte deficiency.
- The system uses methacrylated hyaluronic acid (HAMA) for rapid PDA@PEG release and glyceryl monostearate micelles for MMP-9-responsive G-Exo release at inflammatory sites, enabling spatiotemporal control.
- G-Exos restore redox homeostasis and suppress inflammation, protecting melanocytes and enhancing keratinocyte proliferation.
- PDA@PEG promotes repigmentation via exogenous melanin deposition and endogenous melanogenesis stimulation.
- In murine models, the treatment achieved significant repigmentation in 3 weeks by activating follicular stem cells, upregulating melanogenic markers (Tyr/Mc1r), increasing antioxidant defense (ApoE), and suppressing inflammatory signaling (IL-17).
- The hybrid design leverages biocompatible materials to co-target multiple pathological axes, offering a novel self-adaptive approach for vitiligo microenvironmental rehabilitation.