Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties - PubMed
6 hours ago
- #atrioventricular node
- #biological pacemaker
- #stem cell therapy
- AVN dysfunction causes AV block, managed with electronic pacemakers (EPMs).
- hPSC-derived AVN-like pacemaker cells (AVNLPCs) generated via Wnt/BMP signaling.
- AVNLPCs mimic fetal AVN cells in transcription, action potentials, and conduction.
- Transplanted AVNLPCs replicate AVN function in guinea pig hearts.
- AVNLPC-based BioCB could treat AV block as a novel cell therapy.