Causal neurodevelopmental origins of scoliosis: Multi-omics Mendelian randomization reveals brain-region-specific pathways and protein mediators - PubMed
4 hours ago
- #brain-region pathways
- #Mendelian randomization
- #neurodevelopmental scoliosis
- Childhood viral encephalitis (VE) is associated with a 3.6-fold increased risk of adolescent idiopathic scoliosis (AIS).
- Brain lesions in the corpus callosum and cerebellum show the strongest effects on scoliosis development.
- Seven imaging-derived phenotypes (IDPs) are causally linked to scoliosis, including grey matter volume in the left thalamus and isotropic free water fraction in the cerebellar peduncle.
- Brain protein ERBB4 and cerebrospinal fluid protein LBP mediate 34.9% of the total effect, bridging neuroinflammation to spinal deformity.
- The study supports scoliosis screening programs for children recovering from CNS infections.