Cancer type-specific variation in patterns of driver alterations across 50,000 tumors - PubMed
3 hours ago
- #precision oncology
- #driver alterations
- #HLA genotype
- Study analyzed cancer type-specific patterns of driver alterations across 50,000+ tumors from 48,179 patients, covering 448 histological subtypes.
- One-third of drivers occurred in non-canonical contexts, showing distinct features like increased subclonality, later emergence, and divergent biological properties.
- Gene fusions and co-occurring driver patterns within cancer types were linked to earlier disease onset age.
- Ancestry-specific differences in HLA-restricted driver neoantigens were identified, affecting T cell receptor therapy eligibility.
- Cancer-type-specific patterns of intrinsic resistance via somatic HLA loss were demonstrated.
- The functional roles of driver alterations are highly dependent on cancer type and clinical context.