Gastrointestinal dysfunction after brain injury: Mechanisms and the role of the brain-gut axis - PubMed
a day ago
- #Brain Injury
- #Brain-Gut Axis
- #Gastrointestinal Dysfunction
- Brain injury (BI) includes traumatic BI and stroke, leading to high mortality and morbidity globally.
- Gastrointestinal (GI) dysfunction is a significant sequelae of BI, affecting patient outcomes.
- Common GI dysfunctions post-BI include delayed gastric emptying, increased intestinal permeability, and gut dysbiosis.
- GI dysfunction impairs nutrient absorption, increases infection risk, and exacerbates secondary BI through systemic inflammation.
- The brain-gut axis is a bidirectional communication network between the central and enteric nervous systems.
- Potential treatments for GI dysfunction include probiotics, fecal microbiota transplantation, and vagus nerve stimulation.
- Understanding brain-GI interactions is crucial for developing effective therapies to improve patient survival and quality of life.