Proteomic Analysis of Cerebrospinal Fluid from Severe COVID-19 Patients Reveals Prognostic Biomarkers Associated with Disease Outcome - PubMed
7 hours ago
- #Proteomics
- #Biomarkers
- #COVID-19
- Proteomic analysis of CSF from severe COVID-19 patients identified 488 significantly altered proteins compared to controls.
- Elevated proteins in ICU survivors included those related to coagulation, inflammation, and blood-brain barrier dysfunction (e.g., SERPINC1, KNG1, PLG).
- Non-survivors showed upregulation of proteins linked to metabolic disruption, cellular stress, and neuroinflammation (e.g., FABP3, PDIA4).
- Pathway enrichment analyses highlighted immune activation, inflammatory responses, and coagulation cascades in severe COVID-19.
- Findings suggest CSF proteomics can reveal prognostic biomarkers and highlight systemic inflammation and BBB disruption in COVID-19 pathophysiology.