Estrogen Receptor-Phytoestrogen Interactions in Health and Aging: A Review on Estrogen Receptor Vascular Actions with Proof-of-Concept Data - PubMed
3 hours ago
- #estrogen-receptors
- #phytoestrogens
- #cardiovascular-aging
- The article reviews the interactions between estrogen receptors and phytoestrogens in health and aging, focusing on vascular actions.
- Menopause-related estrogen decline accelerates aging changes like visceral adiposity, insulin resistance, sarcopenia, osteoporosis, and endothelial dysfunction.
- Nutrition and estrogen signaling play interactive roles in healthy aging, though this area remains underexplored.
- Estrogen supports macronutrient utilization, suppresses adipose inflammation, preserves bone density, and promotes endothelial function.
- Phytoestrogens may engage estrogen-responsive pathways to mitigate age-related physiological decline.
- Original experimental data shows GPER agonism enhances vascular responses in female rats, indicating sex-specific estrogen signaling.
- Dietary phytoestrogens and nutrient-rich diets may activate GPER-dependent pathways to support cardiovascular resilience in aging women.
- Precision nutrition strategies targeting GPER are promising for healthy aging, but large-scale human trials are needed.